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High concentrations of active TGF have a definitive effect on induced matrix degradation, 29 inflammation, 30,31 cell migration and cartilage formation

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Doctors call this condition benign prostatic hyperplasia (BPH), or benign prostatic hypertrophy

In some embodiments, the otic formulation comprises between about 0.0001% to about 15% by weight of the weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof