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Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture

89 Additionally, the binding affinity between protein disulfide-isomerase (P4HB) and prostaglandin G/H synthase 2 (PTGS2) is enhanced by lactylation of P4HB at K311, subsequently leading to SH3-domain-containing GRB2-like protein B1 (SH3GLB1)-mediated mtROS accumulation and coiled-coil domain-containing protein 2 (NDP52)-induced mitophagy

Stability varies with formulation, storage conditions, and manufacturer recommendations

Increased oxidative signaling is associated with muscle insulin resistance, atherosclerosis, and muscle wasting [71, 72]

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