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5.2.4 Polyphenol oxidases (PPOs) PPOs are omnipresent Cu-containing enzymes which utilize molecular Oxygen for catalytic hydroxylation and dehydrogenation of o- diphenolic compounds like catechol and caffeic acid to their respective quinones, which leads to the alkylation of nucleophilic groups and self-polymerization to produce dark-coloured melanin polymers [185]

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Copper enters hepatocytes mainly via DMT1 (Cu) and CTR1 (Cu) [13, 17]

Always consult your doctor before starting systemic glutathione IV infusion, especially if you fall into any of these groups or have autoimmune diseases or neurodegenerative disorders

Many find success with a small protein-rich snack in the late morning or afternoon when the medication's appetite suppression lightens slightly