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It plays a role in cysteine storage

As with doxorubicin, cisplatin treatment also results in ROS generation, which is neutralised by the NADPH-powered glutathione system, warranting investigation of this strategy for other forms of chemotherapy which are detoxified via this system

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Subsequent increased capillary membrane permeability and fluid buildup in lungs and explains the development of ARDS requiring the need for mechanical ventilation