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IFN- at high concentrations is a cytokine that also increases intestinal permeability to large molecules (24)

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Biochem Soc Trans 35:10401042 Cooke CL, Davidge ST (2002) Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells

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Taken together, these results demonstrate that C1-27 targets GSTO1 in tumours and shows promising antitumour activity in both cell line xenograft and PDX models of colorectal cancer, without gross systemic toxicities

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