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(2012) Molecular Medicine , 18: 14301436 Randomised, double-blind pilot study confirming safety and efficacy of ARA-290 in sarcoidosis patients with small fibre neuropathy

Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function

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Enhance Lymphatic Drainage Target: Diabetic neuropathy often results in poor circulation and nerve damage, which can contribute to swelling (edema) in the lower extremities