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Call your doctor right away or seek urgent care if you notice: Blood in urine or stool Vomit that looks bloody or dark Coughing up blood Severe headache or confusion Bleeding that does not stop NHS guidance for apixaban lists warning signs such as blood in urine or stool, vomiting blood, coughing blood and sudden severe headache with confusion (NHS, 2026a)

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A significant presence of a GSTP1-1 allelic variant (the GSTP1*C allelic variant) was found in late-onset AD patients 52

Moreover, NSAIDs, known for their toxicity in various organs, remained limited to their damaging effect on the stomach mucosa

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