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Similar to other peptides, it has to be injected subcutaneously and injection sites must be rotated to prevent lipodystrophy

Montesinos MC, Desai D et al (2003): Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68

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The study also detected an increase in IFN- and IFN--driven genes in the tumors indicating the presence of Th 1 immunity in the tumor microenvironment [319]