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B3 works by- Niacinamide inhibits the transfer of melanosomes (pigment-containing organelles) from melanocytes to keratinocytes, which helps reduce hyperpigmentation, including melasma

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As the induction of antioxidant enzymes is a much more potent approach than supplementation with conventional stoichiometric antioxidants, Protandim may be suitable for translational research and may serve as a therapeutic approach for cancer prevention

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Weber authored a review of the research, published early this year, noting the lack of evidence supporting their clinical use