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Description

2007, p

Moderate CYP3A4 inhibitors (diltiazem, naproxen, amiodarone) produce smaller AUC increases (roughly 40% or less) and generally do not require dose adjustment, though clinical judgment applies in patients with multiple risk factors for bleeding [9]

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The concept of lipophilicity, often described qualitatively in terms of hydrophobic surface contribution, is relevant when evaluating reversed-phase chromatographic behaviour