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In db/db mice, a model of T2D with cognitive impairment, intravenous administration of isolated platelet mitochondria was shown to improve cognitive function, reduce oxidative stress, and restore mitochondrial respiratory chain activity in the brain

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High infectivity yield was obtained at residence times greater than 3 min for GSH Sepharose 4 FF and Pierce Glutathione columns, while lower yields were observed across all residence times for GSH Sepharose 4B

Lundgren, P

What this mechanism does NOT prove: Demonstrating a receptor interaction or pathway upregulation in rat tissue or cell culture does not confirm a clinically meaningful effect in humans at any given dose