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The results demonstrated a very strong accumulation of ROS inside the hypoxic cancer cells upon treatment with NP4 but a poor ROS accumulation upon preincubation with NAC and subsequent treatment with NP4 (flow cytometry plots: Fig

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Consequently, it is predicted that the oxidative DNA damage pathway may become relatively dominant in the bioactivation of toremifene in vivo, potentially contributing more significantly to its overall toxicological profile compared to tamoxifen

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