Mitochondrial dysfunction hypothesis Mitochondria, cells energy factories, play a key role in maintaining intracellular calcium homeostasis and signal transduction and provide necessary ATP energy for maintaining normal cell function through the oxidative phosphorylation (OXPHOS) mechanism [43, 44]
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Patients with untreated sleep disorders, patients pregnant or planning pregnancy, patients with active cancer, and patients with unaddressed hormone conditions are not candidates without coordination first