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3,5-diCQM drives melanogenesis in a dose-dependent manner, and the molecular mechanism underlying its ability to induce pigmentation is through activation of the p38 signaling pathway, phosphorylation and activation of CREB, and a cAMP/PKA dependent signaling pathway, which in turn upregulates the transcription factor MITF, thereby activating tyrosinase activity (Kim et al., 2015)

Conversely, ultrasonography can result in compression effects due to the use of the ultrasound probe, potentially leading to misinterpretation of the thicknesses of the skin and subcutaneous layers

It is an endocrine disorder that occurs in approximately one in seven women

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The remaining third of the EDTA-treated plasma was stored at 4 o C without prior deproteinization and was deproteinized immediately prior to analysis