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2.2 The role of inflammation in endometriosis The coordinated action of macrophages, endometrial cells, endothelial cells, and activated lymphocytes, along with cytokines and chemokines, alters the abdominal immune microenvironment, facilitating pathological processes including cell proliferation, angiogenesis, lesion adhesion, growth, and invasion (34)

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HIF-2 directly induces the expression of catabolic factors in chondrocytes, and HIF-2 enhances the expression of Fas, which mediates chondrocyte apoptosis and regulates autophagy in chondrocytes (59)