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In this work, we firstly clarified that oridonin is a Michael acceptor molecule, reacting to thiol group of GSH by an electrophilic addition and covalent bonding

We note that the oncology team, including the oncologist, is responsible for the goals of care discussion and the oncologist is responsible for ensuring documentation of these discussions

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The latter situation is likely to occur in neuroblastoma cells co-treated with DPI and MitoQ and may explain the NAC mediated toxicity