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Docket FDA-2018-N-3240

12511141) and Harbin normal university (HSDSSCX2018-20)

Carotenoids also increase skin resistance to UVB in erythema, potentially reducing phototherapy-induced erythema and stimulating repigmentation in sun-exposed areas, especially when paired with vitamin E 191

Comparable results were reported for synthetic SiNPs in the particle range 7400 nm (Rahman et al., 2009), with our SiNPs being placed in the range of 50150 nm mean particle size, with the formation of some aggregates as well, and with corresponding pore volume and surface area

These reports support the role of oxidative stress in the pathogenesis of SLE [44,45]