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Moreover, obesity activates inflammasomes such as NOD-like receptor family pyrin domain-containing 3 (NLRP3), which is involved in diseases such as non-alcoholic fatty liver disease (NAFLD) (Yu et al., 2022), Type 2 diabetes (Gora et al., 2021), and chronic kidney disease (CKD) (Ke et al., 2018))

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Some believe that, in addition to heightened arousal, individuals with psychophysiological insomnia may have some dysfunctional neurological inhibitory mechanisms that would normally help the mind "disengage" from daytime thought patterns