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It has been suggested that their use over many years could cause physical changes such as shrinkage of the cerebral cortex, as has been shown in chronic alcoholics, and that such changes may be only partially reversible after withdrawal

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Tissue sources for multiplex in situ hybridization Human Tissue blocks covering caudal medulla were obtained from the Edinburgh Brain Bank ( n = 5, including both sexes (two males and three females), aged 5085 years (BBN001.36970, BBN001.37233, BBN001.37268, BBN001.37340, BBN001.37380)) in collaboration with C

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