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However, a landmark July 2025 study published in the Proceedings of the National Academy of Sciences (PNAS) by Shankar, Davis, Bonilla, et al., revealed a fascinating and complex paradox regarding redox homeostasis in these conditions

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Zinc is vital for many aspects of health and has been associated with a variety of benefits

Other HDT agents, such as statins, are associated with muscle-related adverse effects (e.g., myopathy and rhabdomyolysis), especially at high doses or when used in combination with other medications metabolized by the cytochrome P450 system [152]