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Both HTT and huntingtin-interacting protein 1-related protein (HIP1R) appear to undergo O-GlcNAcylation [112, 153], indicating a possible role for O-GlcNAcylation in HD

Consequently CJC 129 without DAC is designed to provide a GHRM-like stimulation around the clock with increased amplitude and longer stimulation, (28 minutes instead of 8-12 of sermorelin), maintaining the natural pulsatile stimulation of the pituitary without decreasing secretion as observed in CJC with DAC

Although additional factors may play a role, the inability to detect new neurons in the adult brain may be due to the different methods of tissue fixation and inconsistencies in long-term storage conditions of the autopsy samples

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Jiang Y, Li W, Wang Z, Lu J