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*Correspondence: Long-you Zhao, [email protected]

In endothelial cells, we observed that SMG exerted several detrimental effects, including elevated ROS production, mitochondrial membrane depolarization, oxidative DNA damage that triggered apoptotic pathways, as well as the upregulation of angiogenic and oxidative stress genes, such as VEGFA, HIF-1, eNOS, and iNOS

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Headache 63(1):104113 Borkum JM (2021) Brain energy deficit as a source of oxidative stress in migraine: a molecular basis for migraine susceptibility