Common gastrointestinal effects (Phase 2 NEJM) Retatrutide GI side effects at 12 mg in the Phase 2 NEJM trial Effect Nausea Rate at 12 mg Up to 25% Effect Diarrhea Rate at 12 mg Up to 23% Effect Vomiting Rate at 12 mg Up to 26% Effect Constipation Rate at 12 mg Up to 16% GI symptoms were most common during dose escalation and were usually mild to moderate
100 Units = 1 ml 1 Unit = 0.01 ml Dose Calculation Examples Using a Reconstitution Calculator While the math is simple, the risk of error is high
Zhang X, Zhang R, Chen H, Wang L, Ren C, Pataer A, Wu S, Meng Q, Ha MJ, Morris J, Xi Y, Wang J, Zhang J, Gibbons D, Heymach J, Meric-Bernstam F, Minna J, Swisher S , Roth J, Fang B
Azathioprine or 6-MP can be considered, but usually neither is recommended for induction therapy because the data on efficacy are limited and the onset of action is slow
This is exactly the concern researchers have been raising