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Here is the practical comparison researchers rely on

PubMed Central , FDA , Feb

We propose that curcumin exerts its broad therapeutic effects via a unified inflammationoxidative stress axis, primarily by inhibiting NF-B and NLRP3 activation, reducing ROS and pro-inflammatory cytokines (TNF-, IL-1/18), as seen across models of depression, metabolic disorders, and neurodegeneration

This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record)

Technically, you can only be perimenopausal or postmenopausal because menopause itself is more like a single point in time than a phase.32 Its when youve officially gone 12 consecutive months without a menstrual period, meaning theyve stopped for good, and youve transitioned from perimenopause to postmenopause