Monteiro et al
Androgen receptors are expressed by murine and human macrophages, monocytes, neutrophils, T cells, and B cells, in which they exhibit predominantly anti-inflammatory and immunosuppressive effects ( In human monocyte-derived macrophages, murine peritoneal macrophages, and human and murine macrophage cell lines (e.g., RAW 264.7 and J774A.1), testosterone dose-dependently inhibited LPS-induced production of nitric oxide (NO) and TNF, as well as expression of inducible nitric oxide synthase (iNOS/ Nos2 ) and TLR4 (110115)
The best choice depends on the main goal, and in many cases a thoughtful mix of both molecules wins
"Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks"
If you use it regularly, it gradually makes the discolouration less obvious