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CNS brain neurons are mainly fueled by glucose metabolized through OXPHOS

Besides Cagrilintide, there are other insulin-based molecules in early clinical trial phases, including long-acting insulin agonists and a dual receptor agonist that binds both insulin and calcitonin activities

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This different localization seems to be evolutionarily retained due to the urge of a wise cellular exploitation of -ketoglutarate that in many organisms acts as a signal and coordinates carbon and nitrogen metabolism [19]

References Pei J, Pan X, Wei G, Hua Y (2023) Research progress of glutathione peroxidase family (GPX) in redoxidation