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When discussing the potential duration of its effects, it is worth mentioning that, despite rapid breakdown, users often report effects that continue for extended periods due to downstream healing and signaling responses

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The 2-4 week window is not a hard cutoff

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Combined therapy with a single 100-mg dose of guselkumab and secukinumab 300 mg every 4 weeks may be effective for short-term control in patients who experience psoriasis flares