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A slight modification of the eCATH-3 peptide (LLK-eCATH-3) realized by the substitution of only three amino acids caused a higher hydrophobicity and helical content resulting in a dramatic change of the antimicrobial activity

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In a note to investors, analysts at the investment bank Jefferies Financial Group say that although petrelintide demonstrated good tolerability, meaning no side effects such as vomiting and nausea, the amount of weight loss did not match that of Lillys amylin molecule