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Body Composition Changes: More significant changes, such as a reduction in body fat or noticeable weight loss, typically occur over a period of 48 weeks

Each treatment targets a different mechanism, and the right combination depends on the patients biology

These observations also highlight that therapeutic approaches should be directed at specific aspects of astrocyte reactivity, for example astrocyte Ccl2 production, rather than at attenuating reactivity per se, which may lead to unexpected and undesirable consequences

NAD+ supplementation adds NAD+ from the outside

Modulates GABA system maintaining inhibitory-excitatory balance