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The primary antioxidant defense in cells is mediated through enzymatic and non-enzymatic systems, including factors such as glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), and superoxide dismutase (SOD) ( The Keap1-Nrf2 signaling pathway plays a crucial role in mediating the antioxidant system

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Western blot Protein was extracted from renal tissues or MTEC cells, and concentrations were measured using a BCA protein assay kit

4) is consistent with the ISR signaling profile (Fig