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In laboratory settings it has been studied alongside NAD+ pathway components to assess downstream effects on mitochondrial function

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Further, reference ranges may vary slightly between laboratories, as different testing methods and units may be used

In one study, mice treated with 20mg/kg of 5-amino-1mq three times daily for 11 days experienced a 5.1% reduction in body weight from baseline

Niacin is a necessary cofactor in the anabolic methionine cycle, supporting enzymes like dihydrofolate reductase