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Via high-butyrate diet intervention and adoptive transfer experiments, it confirmed that a high-butyrate diet can induce the differentiation of follicular Tregs through HDAC inhibition, suppress the production of type II collagen (CII)-specific autoantibodies, and reduce joint swelling and bone erosion

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Interestingly, the four-rung -solenoid structure appeared as stable as the naturally occurring -solenoid of the fungal prion HET-s (Wasmer et al., 2008) described later in this review