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Key examples include immunotherapy (eg, pembrolizumab), antimicrobials (eg, minocycline, nitrofurantoin, moxifloxacin, and isoniazid), antihypertensive medications (eg, hydralazine and -methyldopa), complementary and alternative medications or supplements (eg, black cohosh, khat, and Chinese herbal teas), and others (eg, diclofenac, propylthiouracil, atorvastatin, infliximab, and adalimumab)

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This phenomenon is predominantly caused by cobalamin release during hepatic cytolysis and/or decreased cobalamin clearance by the affected liver

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