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TB-500 A synthetic peptide fragment related to thymosin beta-4, commonly researched for its involvement in actin dynamics, cell migration, and tissue remodelling processes

Specific pathogenic bacteria, such as Campylobacter, Escherichia coli, Salmonella and Shigella, produce a toxin called Cytolethal Distending Toxin B (CdtB)

Others consider significant reduction in symptoms a win, especially after years of chronic problems

In patients with moderate to severe UC not requiring admission and with no response to anti-TNF therapy, a second agent should be considered such as vedolizumab, ustekinumab, ozanimod, or one of the new JAK inhibitors