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4-Hydroxynonenal 4-Hydroxynonenal (4HNE) is a lipoperoxidation-derived aldehyde that can damage proteins and DNA through the generation of covalent adducts and is implicated in the control of cell signaling 13,14

The transforming growth factor- (TGF-)TGF- receptor 2 (TGFR2) signaling pathway regulates differentiation, maturation, proliferation, migration, and attachment of both ECs and pericytes [78, 79]

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Furthermore, and irrespective of the above, the decision is in direct contradiction with the provisions of the FIFA World Cup 2026 Competition Regulations, as set out in Article 10.5: "If a player or team official is sent off as a result of a direct or indirect red card (second caution), they will automatically be suspended from their team's subsequent match