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Because the Long R3 form interacts more freely with IGF-1 receptors, with minimal interference from IGFBPs, it is valued in studies examining growth-factor signaling cascades, metabolic responses, and regenerative mechanisms

Yousefifard et al.s meta-analysis established that stem cell efficacy correlates directly with dose and route specificity, yet prior ASD studies relied on suboptimal single-pathway regimens [46]

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