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The first step in methionine catabolism is the generation of S-adenosylmethionine (SAMe), the principal biological methyl donor, in a reaction catalyzed by methionine adenosyltransferase (MAT) [55]

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To recruit participants, the study coordinator utilized a multifaceted approach, employing fliers, newspaper and radio advertisements, online announcements, and word-of-mouth referrals to reach potential subjects in the local Hershey/Harrisburg, PA area

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For longer-term storage, room temperature is not appropriate