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Sleep plays a role in memory consolidation, and neurosteroids, such as PregS and ALLO can modulate activity within brain regions, such as the pedunculopontine tegmentum nucleus implicated in regulation of sleep (248, 254, 255)

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also showed the same trend in knee symptoms and daily activity progression using the mean KOOS score in ten participants with degenerative meniscus tears without osteoarthritis according to Stoller classification after 3 months and 6 months of follow up (i.e., KOOS: 56.6 15.7 baseline, 70.2 16.8 post- 3 months, 72.7 18.5 post- 6 months, p = 0.0007)

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