Within this antioxidant system, DHA was particularly efficient in triggering the upregulation of Gpx4 gene, which encodes for the nuclear, cytosolic, and mitochondrial isoforms of phospholipid-hydroperoxide glutathione peroxidase (PH-GPx/GPx4), the main enzyme protecting cell membranes against lipid peroxidation and capable to reduce oxidized phospholipids in situ
But dont let that fool you, its healing powers extend far beyond gut health
It is also capable of directly reducing OS through scavenging free radicals.[55] In vitro studies have demonstrated a beneficial role for NAC on germ cell survival as a result of its antioxidant properties.[56] The incubation of semen samples with NAC for 20 min significantly reduced ROS levels and resulted in an improvement of sperm motility.[57] In a randomized placebo-controlled study of 120 patients with idiopathic infertility, treatment with 600 mg of NAC daily resulted in a significant improvement in sperm motility in comparison to placebo.[27] In addition, authors evaluated OS measures and reported higher serum total antioxidant capacity and lower total peroxide and OS index in the NAC-treated group compared with the placebo group
Owing to the immense benefits of glutathione, its release by probiotic bacteria could also find important applications in health improvement
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