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[PMC free article: PMC1894911] [PubMed: 15900287] (In human volunteer studies, kava showed moderate inhibition of CYP 2E1 activity [40%] but no effect on CYP 1A2, 2D6 or 3A4, despite evidence in vitro that kava inhibits these isoenzymes

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Autonomic neuropathy Another neuropathic complication of diabetes mellitus is cardiac autonomic neuropathy (CAN), which occurs in as many as 25% of diabetic patients (55)