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Trends in Biochemical Sciences, 34 (2), 8596

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Conclusion: Taken together, our findings suggest that disruption in cholinergic cortical pathways attributable to SVD, rather than cholinergic thalamic pathways, contributed to the motoric cognitive dysfunction in patients with SVD

PR-104 showed linear pharmacokinetics, rapid conversion to PR-104A, and evidence of antitumor activity, including partial responses and prolonged stable disease in some patients (282)

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