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These agents represent novel approaches in overcoming limitations of traditional antifungals, particularly in addressing resistance and improving patient compliance

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292,528 Notably, in vitro studies have demonstrated the potential of zinc limitation strategies to combat carbapenem resistance caused by zinc metallo--lactamases, as evidenced by the restoration of carbapenem susceptibility in Acinetobacter baumannii and improved survival in mice infected with Aspergillus fumigatus when pathogens were starved with zinc chelators

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