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Proteinases and oxidants as targets in the treatment of chronic obstructive pulmonary disease

Glycolytic acceleration generates succinate accumulation, which inhibits succinate dehydrogenase (SDH), stabilizing hypoxia-inducible factor 1 alpha (HIF-1) to drive pro-inflammatory microglial polarization

It has been found to be helpful in the treatment of conditions like Parkinson's disease, Alzheimer's disease, and multiple sclerosis, where oxidative stress plays a role

Combined with machine learning, gut microbiome signatures, such as enrichment of such CRC-associated pathogens, can potentially act as a scalable and non-invasive approach for early CRC and adenomas detection (Tsai et al., 2025)

therefore, also termed as PACE (Paired basic AA Cleaving Enzyme)