Upon exposure to n-3 PUFAs, Th17 cells generated reduced quantities of proinflammatory cytokines like IL-17, IL-22, and IL-23, whereas Treg cells demonstrated elevated production of anti-inflammatory molecules such as Foxp3 ( DHA has been shown to mitigate the conversion of cells into the Th1/Th17 lineage ( 3.1.1.2 n-6 PUFA The n-6 family of PUFAs comprises key members like linoleic acid (LA) and arachidonic acid (AA), which are notably pro-inflammatory in nature
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As a result, we identified multiple signatures associated with cardiorenal dysfunction and hazard ratios, including alterations in tryptophan/kynurenine/indole metabolism, bile acid deconjugation, acyl-carnitine and S1P metabolism, glutaminolysis and mitochondrial dysfunction and L-arginine metabolism to citrulline and creatinine (Figure 7)
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Monge RA, Romn E, Nombela C, Pla J