Lapelusa, M, San Lucas, FA, Iorgulescu, B, Patel, KP, You, YN, Foo, WC, Maru, DM, Kopetz, S , Ludford, K, Morris, VK, Overman, MJ
Genomic DNA analysis identified several variants of APE1 (L104R, E126D, R237A, D283A, D148E, G306A, and G241R) that were over-represented in ALS patients compared to controls
doi: 10.1093/jxb/err437 8 DaQ.WangP.WangM.SunT.JinH.LiuB.et al
In contrast to the partly anti-inflammatory T H 17 cells, the excessive pathogenic T H 17.1 cell population is characterized by a high proliferation rate, as well as resistance to glucocorticoids and the suppressing effects of regulatory T cells (T reg ) [13]
By examining the data, labs can decide if it would be worthwhile to launch a further analysis to investigate the signal