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Commonly encountered agents were summarized by proposed mechanism, evidence tier, and perioperative considerations ( Table 1 )

Natural origin: DSIP is an endogenous peptide, meaning the body naturally produces it as part of normal sleep regulation Non-sedative: DSIP enhances sleep quality without causing sedation, grogginess, or next-day impairment Multifunctional: Beyond sleep, DSIP has demonstrated stress-protective, analgesic, and neuroendocrine regulatory properties No dependence risk: DSIP does not act on GABA receptors and has not shown addictive properties in clinical studies Understanding Sleep Architecture To understand what DSIP is doing, it helps to understand what healthy sleep actually looks like under the hood

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