Dhamala E., Abdelkefi I., Nguyen M., Hennessy T.J., Nadeau H., Near J
doi:10.1074/jbc.M008212200
W.ZhangY.VenkataramanH.VermeulenN
Key determinants of GSH synthesis are the availability of the sulfur amino acid precursor, cysteine, and the activity of the rate-limiting enzyme, glutamate cysteine ligase (GCL), which is composed of a catalytic (GCLC) and a modifier (GCLM) subunit
Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification