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Additionally, in an exploratory post hoc analysis of SURPASS-4 study, tirzepatide delayed the decline in the estimated glomerular filtration rate (eGFR) and reduced the urine albumin-to-creatinine ratio compared with insulin glargine in people with T2D and high cardiovascular risk (mean eGFR was 81 mL/min/1.73 m 2 and median urine albumin creatinine ratio 15 mg/g at baseline) [49,50]

A slowly developing dysfunction of dopaminergic nigrostriatal neurons induced by long-term paraquat administration in rats: an animal model of preclinical stages of Parkinsons disease

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