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Patients are frequently identified with PD only in the presence of tremor and other symptoms, by which time 6080% of the substantia nigra (SN) dopamine neurons have been lost, which occurs 5 to 15 years after the start of neuronal degeneration (Sulzer et al., 2018) (see Figure 1)

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Unlike BPC-157, which is a synthetic fragment with no natural full-length counterpart, TB-500 mirrors an endogenous peptide with well-characterized biological roles including actin sequestration, cell migration promotion, and tissue repair coordination

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Another study in nonhuman primate demonstrated the ability of OECs to remyelinate spinal cord axons following demyelination lesions (Radtke et al., 2004)