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A recent study showed that high expression of SLC7A11 increases the sensitivity of tumor cells to oxidative stress and promotes the growth of primary tumors (Yan et al., 2023)

The biological basis for these actions is GHK (Tripeptide-1), a peptide generated during tissue damage with a very high affinity for copper (Cu 2+ )

Mentkowski KI, Mursleen A, Snitzer JD, Euscher LM, Lang JK

As granulomas mature, they develop fibrous walls and experience a significant decrease in the number of vessels penetrating the structure, which hampers the penetration of anti-TB drugs into the necrotic and hypoxic areas of the granuloma, where M.tb persists [98, 99]

However, prolonged or excessive HIF-1 activity has been linked to inflammation, tissue remodeling, and tumor progression